Since the birth of vehicle automation technology, a lot of studies have discussed the expected degree of effectiveness of these technologies. The vehicle automation technology has generally created significant effects on improving the safety of the vehicle, making the travel much more accessible and safer than before. The Wrong-Way Driving (WWD) crashes, one of the most severe types of crash, usually happens when drivers were driving under the influence (DUI). These types of crashes once occurred, are mostly head-on ones which tend to be more severe than other crash types. The application of vehicle automation technology may be effective in deterring WWD crash since the technology would be helpful for the driver's decision-making, especially for DUI drivers. However, there are few studies on evaluating if automation technology can help to deter WWD crashes. The goal of this paper is to summarize the current vehicle automation technologies and estimate how these technologies are going to mitigate and prevent WWD crashes base on the real case the author did before (2 high-risk locations for WWD happening). The results can provide some insights for researchers to the application of vehicle automation technology in reducing WWD crashes.